According to Hussey, the absence of these two classy batsmen has left a major hole in Pakistan's middle order.
"I think their depth is going to be tested. You take out Younus Khan and Mohammad Yousuf, you are losing two outstanding, classy players and that is going to be a big loss. Particularly in terms of the Test match arena," the Sydney Morning Herald quoted Hussey, as saying.
"It is going to be hard to find those runs, those guys consistently score in Test match cricket," he added.
The West Australian, however, said that he expected Pakistani quicks Mohammad Aamer, Mohammad Asif and Umar Gul and spinner Danish Kaneria to keep Australia on their toes during the first Test to be held in north London this week.
"I think their bowling attack looks outstanding. They are very well balanced and they cover all bases very well. I think run-making for us is going to be tough," he said.
Mohammad Yousuf retires from international cricket
'Batsmen will rejoice Murali's retirement'
Will Lady Gaga be the queen of Facebook?
Angry Germans demand killing of octopus Paul
Cristiano Ronaldo, most searched player on Google