Sent into bat, West Indies women made 137 for five and then bowled out the hosts for 106 in 18.1 overs.
Captain Stafanie Taylor (47) top scored for the Windies while Deandra Dottin (35), Hayley Matthews (27) and Merissa Aguilleira (21) made valuable contributions with the bat.
For India, medium pacer Shikha Pandey picked up two wickets giving away 29 runs.
Chasing the target, India never recovered from an early batting collapse and their innings eventually folded with the loss of six wickets for just 33 runs.
Only three India batters managed double digit scores with captain Harmanpreet Kaur being the top-scorer with a good knock of 43.
Other Indians to score in double digit scores were Deepti Sharma (24) and Meghna Singh (17).
For the West Indies, Anisa Mohammed (3/23) and Deandra Dottin (3/24) took three wickets each.
The Indian women had lost the first T20 International by six wickets.
Image: The West Indies women's cricket team
Photograph courtesy: windiescricket.com