Despite his absence, the Cobras boast of a strong squad that includes South Africa's star batsmen Jean Paul Duminy and Herschelle Gibbs.
Andrew Puttick, who was left out of the original 15-man squad, was drafted in as the replacement for Smith and also named captain.
Squad: Andrew Puttick (captain), Herschelle Gibbs, Jean Paul Duminy, Derek Brand, Ryan Canning, S Engelbrecht, Henry Davids, Claude Henderson, Rory Kleinveldt, Charl Langeveldt, Richard Levi, Justin Ontong, Veron Philander, Francois Plaatjies, Monde Zondeki.