Dhoni, who has been in very good form, will sit out of the match because of back spasm, leaving Virender Sehwag with the task of leading the team.
Tamil Nadu wicketkeeper-batsman Dinesh Karthik will replace Dhoni in the team which is looking to retain its number one position in the ICC Test championship by clinching the two-match series 2-0.
Sehwag does not think too highly of the hosts, terming Bangladesh as "an ordinary Test side" which cannot surprise the Indians.
"Bangladesh can surprise other teams in One-dayers but not in Test cricket. They are an ordinary side in Test. I don't think they can beat us," he said.
"It is not overconfidence but Bangladesh cannot take 20 Indian wickets, even Sri Lanka could not do it. It isdifficult for Bangladesh to beat us," he added.
With India playing not many Tests this year and other teams -- including South Africa, Australia and England -- closely behind them, the visitors will have to get maximum result from the Bangladesh series.
India is expected to maintain their world number one status if they win the series against Bangladesh 2-0 as South Africa, engaged in a Test series against England at home, is left with no chance of toppling the Dhoni-led side.
Even though some of the Indian players, who were part of the just concluded tri-series squad, would be a bit low in morale after losing the final to Sri Lanka, they will have to get over the disappointment and concentrate at the job at hand.
The complexion of the team has also changed after six players, including stalwarts Sachin Tendulkar, Rahul Dravid and VVS Laxman, joining the touring squad.
History also favour India as Bangladesh had never won a Test against their western neighbours out of the five they have played between themselves, the last one at the same venue being a drawn affair with rain severely affecting the game.
The Indians have won by an innings in three matches while the fourth one was won by nine wickets.
For some big names in Indian cricket, it would be a perfect platform to get into the Test mode ahead of the big Test series against South Africa at home next month.
For dashing Virender Sehwag, who has scored just 23 runs in the two innings against Bangladesh, it is a great opportunity to come up with a big knock and continue his good form after his 293 against Sri Lanka last month.
Sehwag can easily demoralise the inexperience Bangladesh bowlers with his early assault but he will have to play cautiously in the first hour if India bats first as there will be some moisture at the Zohur Ahmed Chowdhury Cricket Stadium.
Sehwag's opening partner Gautam Gambhir would want to begin the year in Test cricket with a good performance after a phenomenal 2009 while Tendulkar, who scored a century in the drawn match at this venue in May 2007, is just 30 runs away from achieveing another milestone of 13,000 runs.
Laxman is another batsman who has a poor record against Bangladesh having scored just 41 runs in two innings in his first tour in 2007.
But the stylish right-hander would be eyeing to become only the fifth Indian Test cricketer to complete 7000 runs as he is just 83 runs short of that mark.
Zaheer Khan, who is the third player along with Tendulkar and Dravid to have played all the five Tests against Bangladesh, would also want to make amends for his poor record against the home team having taken just 10 wickets against them.
While the top six batsman of the formidable batting line-up -- Sehwag, Gambhir, Dravid, Tendulkar, Laxman and wicketkeeper and captain Dhoni automatically select themselves in the playing XI, the bowling department will be spearheaded by Zaheer and off-spinner Harbhajan Singh.
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